我们的工作针对自动分析，以量化细菌细菌群体的生长动力学。我们提出了一种创新的方法，通过自动化新的，特定的成本功能的自动化最小化对可变形细胞运动的框架跟踪。这种最小化由专用的玻尔兹曼机器（随机复发神经网络）实现。通过连续的两个成本函数的最小化，对细胞分裂的自动检测进行了类似的处理，从而交替地识别儿童对和父母的识别。我们使用（i）记录模拟细胞菌落的记录来验证提出的自动细胞跟踪算法，这些算法与微流体陷阱和（ii）真实数据密切模仿大肠杆菌的生长动力学。在一批1100个模拟图像框架上，每帧的单元格登记精度范围从94.5％到100％，平均水平很高。我们使用大肠杆菌菌落的实验图像序列（即实际数据）进行的初始测试也产生令人信服的结果，注册精度范围从90％到100％。

Deep neural networks (DNNs) are often used for text classification tasks as they usually achieve high levels of accuracy. However, DNNs can be computationally intensive with billions of parameters and large amounts of labeled data, which can make them expensive to use, to optimize and to transfer to out-of-distribution (OOD) cases in practice. In this paper, we propose a non-parametric alternative to DNNs that's easy, light-weight and universal in text classification: a combination of a simple compressor like gzip with a $k$-nearest-neighbor classifier. Without any training, pre-training or fine-tuning, our method achieves results that are competitive with non-pretrained deep learning methods on six in-distributed datasets. It even outperforms BERT on all five OOD datasets, including four low-resource languages. Our method also performs particularly well in few-shot settings where labeled data are too scarce for DNNs to achieve a satisfying accuracy.

The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

Scoring the factuality of a generated summary involves measuring the degree to which a target text contains factual information using the input document as support. Given the similarities in the problem formulation, previous work has shown that Natural Language Inference models can be effectively repurposed to perform this task. As these models are trained to score entailment at a sentence level, several recent studies have shown that decomposing either the input document or the summary into sentences helps with factuality scoring. But is fine-grained decomposition always a winning strategy? In this paper we systematically compare different granularities of decomposition -- from document to sub-sentence level, and we show that the answer is no. Our results show that incorporating additional context can yield improvement, but that this does not necessarily apply to all datasets. We also show that small changes to previously proposed entailment-based scoring methods can result in better performance, highlighting the need for caution in model and methodology selection for downstream tasks.

The NASA Astrophysics Data System (ADS) is an essential tool for researchers that allows them to explore the astronomy and astrophysics scientific literature, but it has yet to exploit recent advances in natural language processing. At ADASS 2021, we introduced astroBERT, a machine learning language model tailored to the text used in astronomy papers in ADS. In this work we: - announce the first public release of the astroBERT language model; - show how astroBERT improves over existing public language models on astrophysics specific tasks; - and detail how ADS plans to harness the unique structure of scientific papers, the citation graph and citation context, to further improve astroBERT.

Recent work in large language modeling (LLMs) has used fine-tuning to align outputs with the preferences of a prototypical user. This work assumes that human preferences are static and homogeneous across individuals, so that aligning to a a single "generic" user will confer more general alignment. Here, we embrace the heterogeneity of human preferences to consider a different challenge: how might a machine help people with diverse views find agreement? We fine-tune a 70 billion parameter LLM to generate statements that maximize the expected approval for a group of people with potentially diverse opinions. Human participants provide written opinions on thousands of questions touching on moral and political issues (e.g., "should we raise taxes on the rich?"), and rate the LLM's generated candidate consensus statements for agreement and quality. A reward model is then trained to predict individual preferences, enabling it to quantify and rank consensus statements in terms of their appeal to the overall group, defined according to different aggregation (social welfare) functions. The model produces consensus statements that are preferred by human users over those from prompted LLMs (>70%) and significantly outperforms a tight fine-tuned baseline that lacks the final ranking step. Further, our best model's consensus statements are preferred over the best human-generated opinions (>65%). We find that when we silently constructed consensus statements from only a subset of group members, those who were excluded were more likely to dissent, revealing the sensitivity of the consensus to individual contributions. These results highlight the potential to use LLMs to help groups of humans align their values with one another.

2型糖尿病（T2DM）的早期诊断对于及时的治疗干预措施和生活方式改变至关重要。随着医学成像数据在许多患者群体中变得更广泛可用，我们试图研究是否可以在表格学习分类器模型中利用图像衍生的表型数据来预测T2DM的发病率，而无需使用侵入性血液实验室测量。我们表明，使用图像衍生表型的神经网络和决策树模型都可以预测患者T2DM状态的召回评分高达87.6％。我们还提出了与“ Syntha1c编码器”相同的结构的新颖使用，这些结构能够输出模仿血液血红蛋白A1C经验实验室测量值的可解释值。最后，我们证明了T2DM风险预测模型对输入矢量成分中小扰动的敏感性可用于预测从以前看不见的患者人群中取样的协变量的性能。

我们介绍了一项对自然语言（NL）推理的人类通知，开放域和逻辑上复杂且多样的数据集，配备了一阶逻辑（fol）注释。对开本由1,435个示例（独特的结论）组成，每个示例与487组前提之一搭配，这些场所作为规则，可用于演绎理由，以理解每个结论的有效性。前提和结论的逻辑正确性是通过其平行注释来确保的，这些注释会自动由我们的FOL推理引擎验证。除了主要的NL推理任务外，对开本中的NL-FOL对自动构成了使用FOL作为逻辑形式的新的NL-FOL翻译数据集。我们对广泛的实验系统地评估了对中型语言模型（BERT，ROBERTA）进行微调的FOL推理能力，并且在大型语言模型（GPT-NEOX，OPT，OPT，GPT-3，Codex）上促成了很少的射击。对于NL-FOL翻译，我们尝试使用GPT-3和Codex。我们的结果表明，公开可用的最强大的大语言模型之一（LLM），GPT-3 Davinci，仅比随机结果略好，而在一部分集的一部分中，该模型尤其不好，并且在预测该模型方面尤其不好。纠正虚假和未知结论的真实价值。我们的数据集和代码可在https://github.com/yale-lily/folio上找到。

当从人类行为中推断出奖励功能（无论是演示，比较，物理校正或电子停靠点）时，它已证明对人类进行建模作为做出嘈杂的理性选择，并具有“合理性系数”，以捕获多少噪声或熵我们希望看到人类的行为。无论人类反馈的类型或质量如何，许多现有作品都选择修复此系数。但是，在某些情况下，进行演示可能要比回答比较查询要困难得多。在这种情况下，我们应该期望在示范中看到比比较中更多的噪音或次级临时性，并且应该相应地解释反馈。在这项工作中，我们提倡，将每种反馈类型的实际数据中的理性系数扎根，而不是假设默认值，对奖励学习具有重大的积极影响。我们在模拟反馈以及用户研究的实验中测试了这一点。我们发现，从单一反馈类型中学习时，高估人类理性可能会对奖励准确性和遗憾产生可怕的影响。此外，我们发现合理性层面会影响每种反馈类型的信息性：令人惊讶的是，示威并不总是最有用的信息 - 当人类的行为非常卑鄙时，即使在合理性水平相同的情况下，比较实际上就变得更加有用。 。此外，当机器人确定要要求的反馈类型时，它可以通过准确建模每种类型的理性水平来获得很大的优势。最终，我们的结果强调了关注假定理性级别的重要性，不仅是在从单个反馈类型中学习时，尤其是当代理商从多种反馈类型中学习时，尤其是在学习时。

多实施学习（MIL）被广泛用于对病理整体幻灯片图像（WSIS）的计算机辅助解释，以解决缺乏像素或贴片的注释。通常，这种方法直接应用“自然图像驱动”的MIL算法，该算法忽略了WSIS的多尺度（即金字塔）性质。现成的MIL算法通常部署在单个WSIS（例如20x放大倍率）上，而人类病理学家通常以多尺度的方式汇总全球和局部模式（例如，通过放大不同大型）。在这项研究中，我们提出了一种新型的跨尺度注意机制，以明确地将尺度间相互作用汇总到单个MIL网络的克罗恩病（CD）（CD），这是炎症性肠病的一种形式。本文的贡献是两个方面：（1）提出了一种跨尺度注意机制，以从不同分辨率的多尺度相互作用汇总特征； （2）生成差异多尺度注意的可视化，以定位可解释的病变模式。通过训练来自20名CD患者的约250,000 H＆E染色的上升结肠（AC）斑块，在不同尺度上训练30个健康对照样品，我们的方法在曲线下（AUC）得分为0.8924，与基线模型相比达到0.8924。官方实施可在https://github.com/hrlblab/cs-mil上公开获得。